谷胱甘肽水解酶1酶原 (EC 3.4.19.13) (γ-谷氨酰转移酶1) (γ-谷氨酰转肽酶1) (GGT 1) (EC 2.3.2.2) (白三烯C4水解酶) (EC 3.4.19.14) (CD抗原CD224) [切割为: 谷胱甘肽水解酶1重链; 谷胱甘肽水解酶1轻链]
谷胱甘肽水解酶1酶原 (EC 3.4.19.13) (γ-谷氨酰转移酶1) (γ-谷氨酰转肽酶1) (GGT 1) (EC 2.3.2.2) (白三烯C4水解酶) (EC 3.4.19.14) (CD抗原CD224) [切割为: 谷胱甘肽水解酶1重链; 谷胱甘肽水解酶1轻链]
P19440功能描述
裂解细胞外谷胱甘肽(gamma-Glu-Cys-Gly)、谷胱甘肽结合物(如maresin结合物(13R)-S-谷胱甘肽-(14S)-羟基-(4Z,7Z,9E,11E,16Z,19Z)-二十二碳六烯酸, MCTR1)和其他gamma-谷氨酰化合物(如白三烯C4, LTC4)的gamma-谷氨酰键 (PubMed:17924658, PubMed:21447318, PubMed:27791009)。GGT1对谷胱甘肽的代谢释放游离谷氨酸和二肽半胱氨酰-甘氨酸，后者被二肽酶水解为半胱氨酸和甘氨酸 (PubMed:27791009)。在高浓度二肽和某些氨基酸存在下，还能催化转肽反应，将gamma-谷氨酰基团转移给受体氨基酸以形成新的gamma-谷氨酰化合物 (PubMed:17924658, PubMed:21447318, PubMed:7673200, PubMed:7759490, PubMed:8095045, PubMed:8827453)。有助于半胱氨酸稳态、谷胱甘肽稳态以及白三烯LTC4向LTD4的转化。 {ECO:0000269|PubMed:17924658, ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:21447318, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.; FUNCTION: [Isoform 3]: 似乎无催化活性。 {ECO:0000269|PubMed:7689219}.
组织特异性
Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.; TISSUE SPECIFICITY: [Isoform 3]: Lung-specific.
亚细胞定位
Cell membrane
关键词