胶质细胞系源性神经营养因子 (hGDNF) (星形胶质细胞源性营养因子) (ATF)
胶质细胞系源性神经营养因子 (hGDNF) (星形胶质细胞源性营养因子) (ATF)
P39905功能描述
神经营养因子，增强多巴胺能神经元的存活和形态分化，并增加其高亲和力多巴胺摄取 (PubMed:8493557)。通过结合其共受体GFRA1发挥作用，导致RET受体的自磷酸化和激活 (PubMed:10829012, PubMed:25242331, PubMed:31535977)。参与神经嵴的发育 (PubMed:15242795)。 {ECO:0000269|PubMed:10829012, ECO:0000269|PubMed:15242795, ECO:0000269|PubMed:25242331, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:8493557}。
组织特异性
In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.
亚细胞定位
Secreted
关键词