GCNA Q96QF7

生殖细胞核酸性蛋白 (含酸性重复蛋白) (生殖细胞核酸性肽酶) (生殖细胞核抗原)

功能描述

可能通过SUMO依赖性募集到DPCs位点，在DNA-蛋白交联(DPCs)清除中发挥作用，通过保护生殖细胞和早期胚胎免受各种来源的损伤来确保基因组稳定性 (PubMed:30914427)。能够解离拓扑异构酶II (TOP2A) DPCs (By similarity)。 {ECO:0000250|UniProtKB:A0A1D9BZF0, ECO:0000269|PubMed:30914427}。

组织特异性

Expressed in germ cells of the testis (at protein level) (PubMed:27718356). Detected in skeletal muscle, liver, kidney, pancreas, heart, lung and brain (PubMed:11714101). Expressed throughout spermatogenesis, from spermatogonia to elongated spermatids, in normal adult testis (at protein level) (PubMed:33963445).

亚细胞定位

Nucleus