GCH1 P30793

GTP环水解酶1 (EC 3.5.4.16) (GTP环水解酶I) (GTP-CH-I)

蛋白质信息 (UniProt)

GTP环水解酶1 (EC 3.5.4.16) (GTP环水解酶I) (GTP-CH-I)

P30793

功能描述

正向调节脐静脉内皮细胞 (HUVECs) 中的一氧化氮合成。可能参与多巴胺合成。可能调节疼痛敏感性和持续性。Isoform GCH-1 是功能性 enzyme，酶失活 isoforms 的潜在功能仍未知。 {ECO:0000269|PubMed:12176133, ECO:0000269|PubMed:16338639, ECO:0000269|PubMed:17057711, ECO:0000269|PubMed:8068008, ECO:0000269|PubMed:9445252}.

组织特异性

In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).

亚细胞定位

Cytoplasm

关键词

3D-structure Allosteric enzyme Alternative splicing Cytoplasm Disease variant Dystonia GTP-binding Hydrolase Metal-binding Nucleotide-binding

外部链接

UniProt: P30793

NCBI Gene

GeneCards