GAS2L2 Q8NHY3

GAS2样蛋白2 (17号染色体GAS2相关蛋白) (生长停滞特异性蛋白2样2)

功能描述

参与微管和微丝的交联 (PubMed:12584248, PubMed:24706950)。通过与微管正端追踪蛋白（如MAPRE1）相互作用来调节微管动力学和稳定性，以沿着肌动蛋白应力纤维调节微管生长 (PubMed:24706950)。作为支架将三聚体G蛋白复合物招募到ADORA2A，从而增强ADORA2介导的腺苷酸环化酶激活 (By similarity)。调节位于气道中的细胞的纤毛取向和性能 (PubMed:30665704)。 {ECO:0000250|UniProtKB:Q5SSG4, ECO:0000269|PubMed:12584248, ECO:0000269|PubMed:24706950, ECO:0000269|PubMed:30665704}。

组织特异性

Expressed in bronchial and nasal epithelial cells (at protein level) (PubMed:30665704). Expressed in brain, kidney, lung, testis, fallopian tubes, and skeletal muscle (PubMed:12584248, PubMed:30665704). Expressed at low levels in stomach and colon (PubMed:30665704).

亚细胞定位

Cytoplasm, cytoskeleton