GALNT14 Q96FL9

多肽N-乙酰半乳糖胺转移酶14 (EC 2.4.1.41) (多肽GalNAc转移酶14) (GalNAc-T14) (pp-GaNTase 14) (蛋白质-UDP乙酰半乳糖胺转移酶14) (UDP-GalNAc:多肽N-乙酰半乳糖胺转移酶14)

功能描述

催化O-连接寡糖生物合成中的起始反应，即将N-乙酰-D-半乳糖胺残基转移至protein受体上的丝氨酸或苏氨酸残基。对mucin衍生肽底物（如Muc2、Muc5AC、Muc7和Muc13 (-58)）显示活性。可能参与肾脏中的O-糖基化。

组织特异性

Detected in renal tubules (at protein level). Highly expressed in fetal and adult kidney. Widely expressed at low level. Weakly expressed in whole brain, cerebellum, thymus, lung, mammary gland, liver, stomach, small intestine, colon, pancreas, spleen, bladder, uterus, placenta, testis, ovary, skeletal muscle, leukocyte, B-cell, bone marrow, fetal brain, fetal thymus, fetal lung, fetal liver, fetal small intestine, fetal spleen, fetal skeletal and fetus. Detected in renal tubules (at protein level).

亚细胞定位

Golgi apparatus membrane