多肽N-乙酰半乳糖胺转移酶12 (EC 2.4.1.41) (多肽GalNAc转移酶12) (GalNAc-T12) (pp-GaNTase 12) (蛋白-UDP乙酰半乳糖胺转移酶12) (UDP-GalNAc:多肽N-乙酰半乳糖胺转移酶12)
多肽N-乙酰半乳糖胺转移酶12 (EC 2.4.1.41) (多肽GalNAc转移酶12) (GalNAc-T12) (pp-GaNTase 12) (蛋白-UDP乙酰半乳糖胺转移酶12) (UDP-GalNAc:多肽N-乙酰半乳糖胺转移酶12)
Q8IXK2功能描述
催化O-连接寡糖生物合成中的起始反应，即将N-乙酰-D-半乳糖胺残基转移至protein受体上的丝氨酸或苏氨酸残基。对非糖基化肽段如Muc5AC、Muc1a和EA2具有活性，而对Muc2和Muc7无可见活性。对Gal-NAc-Muc5AC糖肽显示酶活性，但对单GalNAc糖基化的Muc1a、Muc2、Muc7和EA2无可见活性。可能在消化器官中粘蛋白型寡糖生物合成的起始步骤中起重要作用。
组织特异性
Widely expressed at different levels of expression. Highly expressed in digestive organs such as small intestine, stomach, pancreas and colon. Expressed at intermediate level in testis, thyroid gland and spleen. Weakly expressed in whole brain, cerebral cortex, cerebellum, fetal brain, bone marrow, thymus, leukocytes, heart, skeletal muscle, liver, lung, esophagus, kidney, adrenal gland, mammary gland, uterus, placenta, ovary and prostate.
亚细胞定位
Golgi apparatus membrane
关键词