半乳糖-3-O-磺基转移酶 2 (Gal3ST-2) (EC 2.8.2.-) (β-半乳糖-3-O-磺基转移酶 2) (Gal-beta-1, 3-GalNAc 3'-磺基转移酶 2) (糖蛋白 β-Gal 3'-磺基转移酶 2)
半乳糖-3-O-磺基转移酶 2 (Gal3ST-2) (EC 2.8.2.-) (β-半乳糖-3-O-磺基转移酶 2) (Gal-beta-1, 3-GalNAc 3'-磺基转移酶 2) (糖蛋白 β-Gal 3'-磺基转移酶 2)
Q9H3Q3功能描述
催化硫酸基团从3'-磷酸腺苷-5'-磷酰硫酸(PAPS)转移至末端非还原性β-半乳糖残基的C-3羟基上(PubMed:11029462, PubMed:14701868, PubMed:15926885)。以相似的效率作用于1型(Gal-beta-1,3-GlcNAc-R)和2型(Gal-beta-1,4-GlcNAc-R)链(PubMed:11029462, PubMed:14701868, PubMed:15926885)。表现出物种依赖性的底物特异性(PubMed:15926885)。参与半乳糖硫酸化，并对乳糖、乳糖-N-四糖(Lc4)、乳糖-N-新四糖(nLc4)、粘蛋白核心2中的Gal-beta-1,4-GlcNAc-beta单元以及癌症抗原Globo H前体Gal-beta-1,3-GlcNAc-beta-1,3-Gal-R等结构表现出底物偏好(PubMed:11029462, PubMed:14701868, PubMed:15926885)。 {ECO:0000269|PubMed:11029462, ECO:0000269|PubMed:14701868, ECO:0000269|PubMed:15926885}.
组织特异性
Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.
亚细胞定位
Golgi apparatus, Golgi stack membrane
关键词