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G6PC3 Q9BUM1

葡萄糖-6-磷酸酶 3 (G-6-Pase 3) (G6Pase 3) (EC 3.1.3.9) (葡萄糖-6-磷酸酶 beta) (G6Pase-beta) ( ubiquitous 葡萄糖-6-磷酸酶催化亚基相关蛋白)

蛋白质信息 (UniProt)

葡萄糖-6-磷酸酶 3 (G-6-Pase 3) (G6Pase 3) (EC 3.1.3.9) (葡萄糖-6-磷酸酶 beta) (G6Pase-beta) ( ubiquitous 葡萄糖-6-磷酸酶催化亚基相关蛋白)

Q9BUM1

功能描述

在内质网中将glucose-6-phosphate水解为glucose。可能与glucose-6-phosphate转运蛋白(SLC37A4/G6PT)形成广泛表达的复合物,负责通过glycogenolysis和gluconeogenesis产生glucose。可能为正常neutrophil功能所必需。{ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222, ECO:0000269|PubMed:13129915}。

组织特异性

Ubiquitously expressed. Highly expressed in skeletal muscle, at intermediate levels in heart, brain, placenta, kidney, colon, thymus, spleen and pancreas. Also detected in testis, prostate, ovary, liver, lung, small intestine and peripheral blood lymphocytes.

亚细胞定位

Endoplasmic reticulum membrane

关键词

Disease variant Endoplasmic reticulum Gluconeogenesis Hydrolase Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix