FXYD1 O00168

磷酸莱曼 (含FXYD结构域离子转运调节因子1) (钠/钾转运ATP酶亚基FXYD1)

功能描述

与钠/钾转运ATPase (NKA) 结合并调节其活性，该酶将Na(+)转运出细胞并将K(+)转运入细胞。在未磷酸化状态下抑制NKA活性，而在磷酸化时刺激其活性。减少NKA beta-1亚基ATP1B1的谷胱甘肽化，从而逆转谷胱甘肽化介导的ATP1B1抑制。通过维持分泌促性腺激素释放激素的神经元的兴奋性，促进女性性发育。 {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239}。

组织特异性

Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.

亚细胞定位

Cell membrane, sarcolemma