FXR2 P51116

RNA结合蛋白FXR2 (FXR2P) (FMR1常染色体同源蛋白2)

功能描述

mRNA结合蛋白，作为mRNA翻译和/或稳定性的调节因子，并且是成体海马神经发生所必需的 (By similarity)。特异性结合靶mRNA 3'-UTR中的AU-rich元件 (AREs) (By similarity)。通过在结合含AREs的mRNA时发生液-液相分离，促进某些相分离的无膜区室的形成：mRNA储存到无膜区室中调节其翻译和/或稳定性 (By similarity)。作为成体海马神经发生的调节因子，通过调节NOG mRNA的翻译和/或稳定性发挥作用，从而阻止齿状回中NOG蛋白的表达 (By similarity)。 {ECO:0000250|UniProtKB:Q61584, ECO:0000250|UniProtKB:Q9WVR4}。

组织特异性

Expressed in all tissues examined including heart, brain, kidney and testis (PubMed:9259278). In brain, present at high level in neurons and especially in the Purkinje cells at the interface between the granular layer and the molecular layer (at protein level) (PubMed:9259278).

亚细胞定位

Cytoplasm, Cytoplasmic ribonucleoprotein granule