4-半乳糖基-N-乙酰氨基葡萄糖苷3-α-L-岩藻糖基转移酶9 (EC 2.4.1.152) (岩藻糖基转移酶9) (岩藻糖基转移酶IX) (Fuc-TIX) (FucT-IX) (半乳糖苷3-L-岩藻糖基转移酶)
4-半乳糖基-N-乙酰氨基葡萄糖苷3-α-L-岩藻糖基转移酶9 (EC 2.4.1.152) (岩藻糖基转移酶9) (岩藻糖基转移酶IX) (Fuc-TIX) (FucT-IX) (半乳糖苷3-L-岩藻糖基转移酶)
Q9Y231功能描述
催化岩藻糖基部分从GDP-beta-L-fucose转移至连接在糖脂和N-或O-连接糖蛋白上的2型乳糖胺（LacNAc, beta-D-Gal-(1->4)-beta-D-GlcNAc-）聚糖内的N-acetyl glucosamine (GlcNAc)，形成alpha(1->3)连接。对远端2型LacNAc及其岩藻糖基化（H型2型LacNAc）和唾液酸化（唾液酸型2型LacNAc）衍生物进行岩藻糖基化，形成参与细胞粘附和分化的Lewis x (Lex) (CD15) 和 Lewis y (Ley) 抗原表位 (PubMed:10386598, PubMed:10622713, PubMed:11278338, PubMed:12107078, PubMed:16282604, PubMed:17335083, PubMed:18395013, PubMed:23192350, PubMed:23263199, PubMed:29593094, PubMed:37202521)。在脑中生成Lex表位，推测在祖神经细胞的神经元干性维持和神经突生长中发挥作用 (By similarity) (PubMed:17335083, PubMed:23000574)。对聚乳糖胺链内部的2型LacNAc单元进行岩藻糖基化以形成VIM-2抗原，该抗原作为SELE的识别表位 (PubMed:23192350)。也能修饰乳寡糖，特别是2型四糖LNnT (PubMed:37202521)。 {ECO:0000250|UniProtKB:O88819, ECO:0000269|PubMed:10386598, ECO:0000269|PubMed:10622713, ECO:0000269|PubMed:11278338, ECO:0000269|PubMed:12107078, ECO:0000269|PubMed:16282604, ECO:0000269|PubMed:17335083, ECO:0000269|PubMed:18395013, ECO:0000269|PubMed:23000574, ECO:0000269|PubMed:23192350, ECO:0000269|PubMed:23263199, ECO:0000269|PubMed:29593094, ECO:0000269|PubMed:37202521}.
组织特异性
Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus (PubMed:10386598). Highly expressed in granulocytes. Not expressed in monocytes (PubMed:11278338).
亚细胞定位
Golgi apparatus, trans-Golgi network membrane
关键词