卵泡抑素相关蛋白3 (卵泡抑素样蛋白3) (卵泡抑素相关基因蛋白)
卵泡抑素相关蛋白3 (卵泡抑素样蛋白3) (卵泡抑素相关基因蛋白)
O95633功能描述
异构体1或分泌型是TGF-beta家族成员（如activin、BMP2和MSTN）的结合和拮抗蛋白。抑制activin A-、activin B-、BMP2-和MSDT诱导的细胞信号传导；对activin A的作用比对activin B更有效。参与骨形成；抑制破骨细胞分化。参与造血；参与造血祖细胞的分化，增加造血细胞对纤连蛋白的粘附，似乎有助于造血前体细胞对骨髓基质的粘附。异构体2或核型可能通过与MLLT10相互作用参与转录调控。 {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}。
组织特异性
Expressed in a wide range of tissues.
亚细胞定位
[Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to.
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