FRZB Q92765

分泌型卷曲相关蛋白 3 (sFRP-3) (Frezzled) (Fritz) (卷曲相关蛋白 1) (FrzB-1)

功能描述

可溶性卷曲相关蛋白 (sFRPS) 通过与Wnts直接相互作用，作为Wnt信号传导的调节因子。它们在特定细胞类型的细胞生长和分化调节中具有作用。SFRP3/FRZB似乎参与肢体骨骼发生。Wnt8信号传导的拮抗剂。调节软骨细胞成熟和长骨发育。

组织特异性

Expressed primarily in the cartilaginous cores of the long bone during embryonic and fetal development and in the appendicular skeleton (6-13 weeks). At 13 weeks of gestation, transcripts were present in early chondroblasts of the tarsal bones of the foot, the carpal bones of the hands and the epiphysis of long bones. Highly expressed in placenta and heart, followed by brain, skeletal muscle, kidney and pancreas. Weakly expressed in lung and liver.

亚细胞定位

Secreted