FOCAD Q5VW36

聚焦黏附蛋白

功能描述

维持肝脏中SKIC2和SKIC3蛋白稳态水平所必需。可能参与外切体复合物对RNA降解的调节 (PubMed:35864190)。神经胶质瘤中的潜在肿瘤抑制因子。 {ECO:0000250, ECO:0000269|PubMed:22427331, ECO:0000269|PubMed:35864190}。

组织特异性

Ubiquitous. High expression in brain followed by testis, muscle, pancreas, heart, ovary, small intestine, placenta, prostate, thymus, kidney, colon, liver, lung, spleen and leukocytes. Expression is reduced in most glioblastomas and all glioblastoma cell lines.

亚细胞定位

Cell junction, focal adhesion