Formin结合蛋白1 (Formin结合蛋白17) (hFBP17)
Formin结合蛋白1 (Formin结合蛋白17) (hFBP17)
Q96RU3功能描述
可能作为RND2信号传导与肌动蛋白细胞骨架调节之间的连接 (By similarity)。在网格蛋白介导的内吞作用晚期，协调膜小管形成与肌动蛋白细胞骨架重组所必需。结合脂质，如磷脂酰肌醇4,5-二磷酸和磷脂酰丝氨酸，并促进膜内陷和小管形成。还通过招募WASL/N-WASP增强肌动蛋白聚合，进而激活Arp2/3复合物。肌动蛋白聚合可能促进膜小管断裂形成内吞囊泡。FASLG/FASL的溶酶体滞留可能需要该蛋白。 {ECO:0000250, ECO:0000269|PubMed:15252009, ECO:0000269|PubMed:16318909, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:16418535, ECO:0000269|PubMed:17512409}。
组织特异性
Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.
亚细胞定位
Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
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