纤连蛋白 (FN) (冷不溶性球蛋白) (CIG) [裂解为：Anastellin；Ugl-Y1；Ugl-Y2；Ugl-Y3]
纤连蛋白 (FN) (冷不溶性球蛋白) (CIG) [裂解为：Anastellin；Ugl-Y1；Ugl-Y2；Ugl-Y3]
P02751功能描述
纤连蛋白结合细胞表面及包括胶原蛋白、纤维蛋白、肝素、DNA和肌动蛋白在内的多种化合物 (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369)。纤连蛋白参与细胞粘附、细胞运动、调理作用、伤口愈合以及细胞形态的维持 (PubMed:3024962, PubMed:3593230, PubMed:3900070, PubMed:7989369)。通过纤连蛋白原纤维形成细胞介导的基质组装过程参与成骨细胞压实，这对成骨细胞矿化至关重要 (By similarity)。参与成骨细胞I型胶原蛋白沉积的调节 (By similarity)。作为LILRB4受体的配体，抑制FCGR1A/CD64介导的单核细胞活化 (PubMed:34089617)。 {ECO:0000250|UniProtKB:P11276, ECO:0000269|PubMed:3024962, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:3593230, ECO:0000269|PubMed:3900070, ECO:0000269|PubMed:7989369}.; FUNCTION: [Anastellin]: 结合纤连蛋白并诱导原纤维形成。这种纤连蛋白聚合物称为超纤连蛋白，表现出增强的粘附特性。Anastellin和超纤连蛋白均抑制肿瘤生长、血管生成和转移。Anastellin激活p38 MAPK并抑制溶血磷脂信号传导。 {ECO:0000269|PubMed:11209058, ECO:0000269|PubMed:15665290, ECO:0000269|PubMed:19379667, ECO:0000269|PubMed:8114919}.; FUNCTION: 由收缩的肌肉分泌，通过肝脏ITGA5:ITGB1整合素受体信号传导诱导肝脏自噬（一种用于营养动员和损伤清除的降解途径）以及全身胰岛素增敏。 {ECO:0000250|UniProtKB:P11276}.
组织特异性
Expressed in the inner limiting membrane and around blood vessels in the retina (at protein level) (PubMed:29777959). Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine (PubMed:17614963).
亚细胞定位
Secreted, extracellular space, extracellular matrix
关键词