受体型酪氨酸蛋白激酶FLT3 (EC 2.7.10.1) (FL细胞因子受体) (胎肝激酶-2) (FLK-2) (Fms样酪氨酸激酶3) (FLT-3) (干细胞酪氨酸激酶1) (STK-1) (CD抗原CD135)
受体型酪氨酸蛋白激酶FLT3 (EC 2.7.10.1) (FL细胞因子受体) (胎肝激酶-2) (FLK-2) (Fms样酪氨酸激酶3) (FLT-3) (干细胞酪氨酸激酶1) (STK-1) (CD抗原CD135)
P36888功能描述
酪氨酸蛋白激酶，作为细胞因子FLT3LG的细胞表面受体，调节造血祖细胞和树突状细胞的分化、增殖和存活。促进SHC1和AKT1的磷酸化，以及下游效应器MTOR的激活。促进RAS信号传导的激活和下游激酶的磷酸化，包括MAPK1/ERK2和/或MAPK3/ERK1。促进FES、FER、PTPN6/SHP、PTPN11/SHP-2、PLCG1以及STAT5A和/或STAT5B的磷酸化。野生型FLT3的激活仅引起STAT5A或STAT5B的微弱激活。导致激酶组成型活性的突变通过激活多种信号通路促进细胞增殖并抵抗凋亡。 {ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:16266983, ECO:0000269|PubMed:16627759, ECO:0000269|PubMed:18490735, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21067588, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:7507245}。
组织特异性
Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.
亚细胞定位
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation.
关键词