FLG2 Q5D862

丝聚蛋白-2 (FLG-2) (中间丝相关及银屑病易感蛋白) (Ifapsoriasin)

功能描述

对于角质化细胞层中正常的细胞-细胞粘附至关重要 (PubMed:29758285)。对于表皮角质层的正常完整性和机械强度很重要 (PubMed:29505760)。 {ECO:0000269|PubMed:29505760, ECO:0000269|PubMed:29758285}。

组织特异性

Expressed in skin, thymus, stomach and placenta, but not detected in heart, brain, liver, lung, bone marrow, small intestine, spleen, prostate, colon, adrenal gland, kidney, pancreas, mammary gland, bladder, thyroid, salivary gland and trachea. Weakly expressed in esophagus, tonsils and testis (at protein level). In the skin, strongly expressed in the upper stratum granulosum and lower stratum corneum, but not detected in the upper stratum corneum (at protein level) (PubMed:19384417, PubMed:21531719). In scalp hair follicles, mainly restricted within the granular and cornified cells surrounding the infundibular outer root sheath, with weak expression in central and proximal outer root sheath (at protein level). Tends to be down-regulated in sporiatic lesions compared to non-lesional skin inthe same patients (PubMed:19384417).

亚细胞定位

Cytoplasm