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FHL1 Q13642

四个半LIM结构域蛋白1 (FHL-1) (骨骼肌LIM蛋白1) (SLIM) (SLIM-1)

蛋白质信息 (UniProt)

四个半LIM结构域蛋白1 (FHL-1) (骨骼肌LIM蛋白1) (SLIM) (SLIM-1)

Q13642

功能描述

可能参与肌肉发育或肥大。

组织特异性

Isoform 1 is highly expressed in skeletal muscle and to a lesser extent in heart, placenta, ovary, prostate, testis, small intestine, colon and spleen. Expression is barely detectable in brain, lung, liver, kidney, pancreas, thymus and peripheral blood leukocytes. Isoform 2 is expressed in brain, skeletal muscle and to a lesser extent in heart, colon, prostate and small intestine. Isoform 3 is expressed in testis, heart and skeletal muscle.

亚细胞定位

[Isoform 1]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm, cytosol. Note=Predominantly nuclear in myoblasts but is cytosolic in differentiated myotubes.

关键词

3D-structure Acetylation Alternative splicing Cytoplasm Developmental protein Differentiation Direct protein sequencing Disease variant Emery-Dreifuss muscular dystrophy Isopeptide bond