成纤维细胞生长因子受体1 (FGFR-1) (EC 2.7.10.1) (碱性成纤维细胞生长因子受体1) (BFGFR) (bFGF-R-1) (Fms样酪氨酸激酶2) (FLT-2) (N-sam) (原癌基因c-Fgr) (CD抗原CD331)
成纤维细胞生长因子受体1 (FGFR-1) (EC 2.7.10.1) (碱性成纤维细胞生长因子受体1) (BFGFR) (bFGF-R-1) (Fms样酪氨酸激酶2) (FLT-2) (N-sam) (原癌基因c-Fgr) (CD抗原CD331)
P11362功能描述
酪氨酸蛋白激酶，作为成纤维细胞生长因子的细胞表面受体，在胚胎发育、细胞增殖、分化和迁移的调节中起重要作用。胚胎发育期间正常中胚层模式形成和正确轴向组织、正常骨骼发生以及促性腺激素释放激素 (GnRH) 神经系统正常发育所必需的。磷酸化PLCG1、FRS2、GAB1和SHB。配体结合导致多种信号级联反应的激活。PLCG1的激活导致细胞信号分子二酰甘油和1,4,5-三磷酸肌醇的产生。FRS2的磷酸化触发GRB2、GAB1、PIK3R1和SOS1的募集，并介导RAS、MAPK1/ERK2、MAPK3/ERK1和MAP激酶信号通路以及AKT1信号通路的激活。促进SHC1、STAT1和PTPN11/SHP2的磷酸化。在细胞核内，增强RPS6KA1和CREB1活性并有助于转录调节。FGFR1信号传导受IL17RD/SEF以及FGFR1泛素化、内化和降解的下调。 {ECO:0000250|UniProtKB:P16092, ECO:0000269|PubMed:10830168, ECO:0000269|PubMed:11353842, ECO:0000269|PubMed:12181353, ECO:0000269|PubMed:1379697, ECO:0000269|PubMed:1379698, ECO:0000269|PubMed:15117958, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18480409, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19261810, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:20133753, ECO:0000269|PubMed:20139426, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:8622701, ECO:0000269|PubMed:8663044}.
组织特异性
Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
亚细胞定位
Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.
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