成纤维细胞生长因子结合蛋白 1 (FGF-BP) (FGF-BP1) (FGF结合蛋白 1) (FGFBP-1) (17 kDa 肝素结合生长因子结合蛋白) (17 kDa HBGF结合蛋白) (HBp17)
成纤维细胞生长因子结合蛋白 1 (FGF-BP) (FGF-BP1) (FGF结合蛋白 1) (FGFBP-1) (17 kDa 肝素结合生长因子结合蛋白) (17 kDa HBGF结合蛋白) (HBp17)
Q14512功能描述
作为一种载体蛋白，从细胞外基质 (EM) 储存中释放成纤维细胞结合因子 (FGFs)，从而增强 FGFs 的促有丝分裂活性。在组织修复、血管生成和肿瘤生长过程中增强 FGF2 信号传导。 {ECO:0000269|PubMed:11509569, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:9334727}。
组织特异性
Expressed in the suprabasal region of the epidermis, in hair follicles, the basement membrane at the dermo-epidermal junction (occasionally extending into the basement membrane of dermal blood vessels), wounded skin and several invasive squamous cell carcinomas (at protein level). Expressed in normal and wounded skin and various squamous cell carcinomas.
亚细胞定位
Secreted, extracellular space
关键词