成纤维细胞生长因子23 (FGF-23) (磷调控蛋白) (肿瘤源性低血磷诱导因子) [裂解为：成纤维细胞生长因子23 N端肽; 成纤维细胞生长因子23 C端肽]
成纤维细胞生长因子23 (FGF-23) (磷调控蛋白) (肿瘤源性低血磷诱导因子) [裂解为：成纤维细胞生长因子23 N端肽; 成纤维细胞生长因子23 C端肽]
Q9GZV9功能描述
磷酸盐稳态调节因子 (PubMed:11062477)。通过降低SLC34A1水平抑制肾小管磷酸盐转运 (PubMed:11409890)。在KL存在下上调EGR1表达 (By similarity)。直接作用于甲状旁腺以减少PTH分泌 (By similarity)。维生素D代谢调节因子 (PubMed:15040831)。负向调节成骨细胞分化和基质矿化 (PubMed:18282132)。 {ECO:0000250|UniProtKB:Q8VI82, ECO:0000269|PubMed:11062477, ECO:0000269|PubMed:11409890, ECO:0000269|PubMed:15040831, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18282132}。
组织特异性
Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).
亚细胞定位
Secreted
关键词