FGF2 P09038

成纤维细胞生长因子2 (FGF-2) (碱性成纤维细胞生长因子) (bFGF) (肝素结合生长因子2) (HBGF-2)

蛋白质信息 (UniProt)

成纤维细胞生长因子2 (FGF-2) (碱性成纤维细胞生长因子) (bFGF) (肝素结合生长因子2) (HBGF-2)

P09038

功能描述

作为FGFR1、FGFR2、FGFR3和FGFR4的配体 (PubMed:8663044)。也作为整合素配体，这是FGF2信号传导所必需的 (PubMed:28302677)。结合整合素ITGAV:ITGB3 (PubMed:28302677)。在细胞存活、细胞分裂、细胞分化和细胞迁移的调节中起重要作用 (PubMed:28302677, PubMed:8663044)。在体外作为强效有丝分裂原起作用 (PubMed:1721615, PubMed:3732516, PubMed:3964259)。能诱导血管生成 (PubMed:23469107, PubMed:28302677)。介导ERK1/2的磷酸化，从而促进视网膜晶状体纤维分化 (PubMed:29501879)。 {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:29501879, ECO:0000269|PubMed:3732516, ECO:0000269|PubMed:3964259}。

组织特异性

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue.

亚细胞定位

Secreted

关键词

3D-structure Alternative initiation Angiogenesis Developmental protein Differentiation Direct protein sequencing Growth factor Heparin-binding Isopeptide bond Methylation

外部链接

UniProt: P09038

NCBI Gene

GeneCards