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FGF12 P61328

成纤维细胞生长因子12 (FGF-12) (成纤维细胞生长因子同源因子1) (FHF-1) (肌细胞激活因子)

蛋白质信息 (UniProt)

成纤维细胞生长因子12 (FGF-12) (成纤维细胞生长因子同源因子1) (FHF-1) (肌细胞激活因子)

P61328

功能描述

参与神经系统发育和功能。参与电压门控钠通道活性的正调控。通过提高神经元钠通道SCN8A快速失活的电压依赖性来促进神经元兴奋性。 {ECO:0000269|PubMed:27164707}。

组织特异性

Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.

亚细胞定位

Nucleus

关键词

3D-structure Alternative splicing Disease variant Epilepsy Growth factor Nucleus Proteomics identification Reference proteome