FES P07332

酪氨酸蛋白激酶Fes/Fps (EC 2.7.10.2) (猫肉瘤/藤浪禽肉瘤癌基因同源物) (原癌基因c-Fes) (原癌基因c-Fps) (p93c-fes)

功能描述

酪氨酸蛋白激酶，作用于细胞表面受体下游，在肌动蛋白细胞骨架、微管组装、细胞附着和细胞铺展的调节中发挥作用。在肥大细胞的FCER1（高亲和力免疫球蛋白epsilon受体）介导的信号传导中发挥作用。作用于激活的FCER1受体和肥大/干细胞生长因子受体KIT下游。在肥大细胞脱颗粒的调节中发挥作用。在细胞分化调节中发挥作用，并促进响应NGF信号的神经突生长。在响应HGF诱导的EZR激活的细胞散射和细胞迁移中发挥作用。磷酸化BCR并下调BCR激酶活性。磷酸化HCLS1/HS1、PECAM1、STAT3和TRIM28。 {ECO:0000269|PubMed:11509660, ECO:0000269|PubMed:15302586, ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:16455651, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:19001085, ECO:0000269|PubMed:19051325, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:2656706, ECO:0000269|PubMed:8955135}。

组织特异性

Widely expressed. Detected in adult colon epithelium (at protein level) (PubMed:16455651, PubMed:19051325). Expressed in melanocytes (at protein level) (PubMed:28463229).

亚细胞定位

Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.