FERMT1 Q9BQL6

Fermitin家族同源物1 (Kindlerin) (Kindlin综合征蛋白) (Kindlin-1) (Unc-112相关蛋白1)

功能描述

参与细胞黏附。促进整合素激活。当与talin共表达时，增强ITGA2B的激活。正常角质形成细胞增殖所必需。皮肤基底角质形成细胞的正常极化和正常细胞形态所必需。角质形成细胞与纤连蛋白和层粘连蛋白的正常黏附，以及角质形成细胞向伤口部位的正常迁移所必需。可能在肿瘤进展中介导TGF-beta 1信号传导。 {ECO:0000269|PubMed:14634021, ECO:0000269|PubMed:17012746, ECO:0000269|PubMed:19804783}。

组织特异性

Expressed in brain, skeletal muscle, kidney, colon, adrenal gland, prostate, and placenta. Weakly or not expressed in heart, thymus, spleen, liver, small intestine, bone marrow, lung and peripheral blood leukocytes. Overexpressed in some colon and lung tumors. In skin, it is localized within the epidermis and particularly in basal keratocytes. Not detected in epidermal melanocytes and dermal fibroblasts.

亚细胞定位

Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Constituent of focal adhesions. Localized at the basal aspect of skin keratinocytes, close to the cell membrane. Colocalizes with filamentous actin. Upon TGFB1 treatment, it localizes to membrane ruffles.