FCRL5 Q96RD9

Fc受体样蛋白5 (FcR样蛋白5) (FcRL5) (BXMAS1) (Fc受体同源物5) (FcRH5) (免疫受体易位相关蛋白2) (CD抗原CD307e)

功能描述

在B细胞对抗原的反应中起重要作用，既作为阴性共受体也作为阳性共受体。在缺乏CR2刺激时抑制B细胞受体(BCR)信号传导，但与CR2和BCR结合后，相比于CR2和BCR共刺激，能引起更强的钙反应(PubMed:30107486)。可能参与外周淋巴器官中B细胞的发育和分化，并可能作为B细胞阶段的有用标志物。可能在边缘区B细胞中具有免疫调节作用。可能在受精过程中发挥作用(By similarity)。 {ECO:0000250|UniProtKB:Q68SN8, ECO:0000269|PubMed:11453668}。

组织特异性

Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).

亚细胞定位

Cell membrane