FCRL3 Q96P31

Fc受体样蛋白3 (FcR样蛋白3) (FcRL3) (Fc受体同源物3) (FcRH3) (IFGP家族蛋白3) (hIFGP3) (免疫受体易位相关蛋白3) (MAIA) (含SH2域磷酸酶锚定蛋白2) (CD抗原CD307c)

功能描述

促进TLR9诱导的B细胞增殖、活化和存活，但抑制抗体产生并抑制浆细胞分化。增强TLR9刺激的B细胞中NF-kappa-B和MAPK信号通路的活化 (PubMed:23857366)。对B细胞受体(BCR)介导的信号转导具有抑制作用，可能是通过与含SH2结构域的磷酸酶结合实现的。抑制由BCR信号诱导的细胞酪氨酸磷酸化、钙动员和活化诱导的细胞死亡 (PubMed:19843936)。表达FCRL3的调节性T细胞表现出记忆表型，在IL2存在下对抗原刺激相对无反应，并且抑制效应T细胞增殖的能力降低 (PubMed:19494275, PubMed:20190142)。作为卵母细胞表面（卵质膜）的人类特异性表位，在精子-卵子粘附和融合过程中发挥作用 (PubMed:36070373)。与IZUMO1-IZUMO1R/JUNO精子-卵子复合物相互作用，并在受精过程中替代IZUMO1R/JUNO作为IZUMO1受体，从而允许物种特异性的配子融合 (PubMed:36070373)。 {ECO:0000269|PubMed:19494275, ECO:0000269|PubMed:19843936, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:23857366, ECO:0000269|PubMed:36070373}.

组织特异性

Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366). Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level) (PubMed:20190142). Expressed in unfertilized oocytes (at protein level) (PubMed:36070373). Expressed in a population of thymically derived naturally occurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142). Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus.

亚细胞定位

Cell membrane