FCMR O60667

免疫球蛋白mu Fc受体 (IgM FcR) (Fas凋亡抑制分子3) (FAIM3) (Fas诱导凋亡调节因子Toso)

功能描述

免疫球蛋白M (IgM)的高亲和力Fc受体，包括分泌型和膜结合型IgM (PubMed:19858324, PubMed:22675200, PubMed:36949194, PubMed:37095205)。主要调节IgM的转运和稳态。在淋巴细胞中，促进膜结合型IgM在质膜上的胞吐以及IgM-抗原复合物向溶酶体的内吞以进行降解。在黏膜上皮中，介导抗原-IgM复合物经黏膜M细胞逆向转运至黏膜淋巴组织中的抗原呈递细胞 (PubMed:21908732, PubMed:28230186)。触发共刺激信号并介导参与B细胞发育和感染初级免疫应答的大多数IgM效应功能。可能限制针对自身抗原的张力性IgM BCR信号，以利于骨髓中自身反应性B细胞的正确阴性选择以及外周淋巴器官中调节性B细胞库的维持。介导对T细胞依赖性和T细胞非依赖性抗原的抗体应答，并促进诱导有效的中和性IgG应答。通过非经典NF-kappa-B、MAP激酶和钙信号通路与抗原受体信号进行交互对话 (PubMed:19858324, PubMed:22675200, PubMed:25601920, PubMed:30840890)。 {ECO:0000269|PubMed:19858324, ECO:0000269|PubMed:21908732, ECO:0000269|PubMed:22675200, ECO:0000269|PubMed:25601920, ECO:0000269|PubMed:28230186, ECO:0000269|PubMed:30840890, ECO:0000269|PubMed:36949194, ECO:0000269|PubMed:37095205}。

组织特异性

Expressed by CD19-positive B cells and CD4-positive and CD8-positive T cell populations in primary and secondary lymphoid tissues (at protein level). Among B cell subsets, detected in a subset of bone marrow pro- and pre-B cells, in most follicular and memory B cells and in a small subset of germinal center B cells (at protein level). Expressed at lower levels in CD56-positive NK cells (at protein level) (PubMed:19858324, PubMed:21908732, PubMed:22675200, PubMed:30840890). Expressed in lymph nodes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland.

亚细胞定位

Cell membrane