FATE1 Q969F0

胎儿和成人睾丸表达转录本蛋白 (癌/睾丸抗原43) (CT43) (肿瘤抗原BJ-HCC-2)

功能描述

参与内质网(ER)-线粒体偶联的调节。负向调节ER-线粒体间距以及从ER到线粒体的Ca(2+)转移，可能暗示其参与细胞凋亡的调节 (PubMed:27402544)。可能与RNF183协作以限制BIK蛋白水平，从而调节凋亡信号 (PubMed:26567849)。 {ECO:0000269|PubMed:27402544, ECO:0000305|PubMed:26567849}。

组织特异性

Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919).

亚细胞定位

Mitochondrion