胃促素 (GT) (脂肪酸结合蛋白6) (回肠脂质结合蛋白) (ILBP) (肠道15 kDa蛋白) (I-15P) (肠道胆汁酸结合蛋白) (I-BABP)
胃促素 (GT) (脂肪酸结合蛋白6) (回肠脂质结合蛋白) (ILBP) (肠道15 kDa蛋白) (I-15P) (肠道胆汁酸结合蛋白) (I-BABP)
P51161功能描述
结合胆汁酸，参与肠肝胆汁酸代谢。回肠肠细胞中结合胆汁酸从顶端到基底外侧的有效运输所必需 (By similarity)。体外结合胆汁酸的顺序为：脱氧胆酸 > 胆酸 > 鹅脱氧胆酸，相应的胆汁酸结合修饰改变亲和力的顺序为牛磺酸结合型 > 甘氨酸结合型 > 非结合型胆汁酸。刺激胃酸和胃蛋白酶原分泌 (By similarity)。 {ECO:0000250|UniProtKB:P10289, ECO:0000250|UniProtKB:P51162, ECO:0000269|PubMed:12486725, ECO:0000269|PubMed:7588781}.; FUNCTION: [Isoform 2]: 结肠癌细胞在胆汁酸诱导的细胞凋亡中存活所必需。 {ECO:0000269|PubMed:17909007}.
组织特异性
Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is xpressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum. Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level).
亚细胞定位
[Isoform 1]: Cytoplasm
关键词