F9 P00740

凝血因子IX (EC 3.4.21.22) (Christmas因子) (血浆凝血活酶成分) (PTC) [切割为：凝血因子IXa轻链；凝血因子IXa重链]

蛋白质信息 (UniProt)

凝血因子IX (EC 3.4.21.22) (Christmas因子) (血浆凝血活酶成分) (PTC) [切割为：凝血因子IXa轻链；凝血因子IXa重链]

P00740

功能描述

因子IX是一种维生素K依赖性血浆蛋白，在Ca(2+)离子、磷脂和因子VIIIa存在的情况下，通过将因子X转化为其活性形式参与血液凝固的内源性途径 (PubMed:8295821, PubMed:2592373, PubMed:20121197, PubMed:20121198, PubMed:1730085, PubMed:19846852, PubMed:39880037)。 {ECO:0000269|PubMed:1730085, ECO:0000269|PubMed:19846852, ECO:0000269|PubMed:20121197, ECO:0000269|PubMed:20121198, ECO:0000269|PubMed:2592373, ECO:0000269|PubMed:39880037, ECO:0000269|PubMed:8295821}。

组织特异性

Detected in blood plasma (at protein level) (PubMed:19846852, PubMed:2592373, PubMed:3857619, PubMed:8295821, PubMed:9169594). Synthesized primarily in the liver and secreted in plasma.

亚细胞定位

Secreted

关键词

3D-structure Alternative splicing Blood coagulation Calcium Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond EGF-like domain Gamma-carboxyglutamic acid

外部链接

UniProt: P00740

NCBI Gene

GeneCards