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ETS1 P14921

C-ets-1蛋白 (p54)

蛋白质信息 (UniProt)

C-ets-1蛋白 (p54)

P14921

功能描述

转录因子 (PubMed:10698492, PubMed:11909962)。在多种不同的细胞环境中直接控制细胞因子和趋化因子基因的表达 (PubMed:20378371)。可能控制淋巴细胞的分化、存活和增殖 (PubMed:20378371)。也可能通过调节控制内皮细胞迁移和侵袭的基因表达来调节血管生成 (PubMed:15247905, PubMed:15592518)。 {ECO:0000269|PubMed:10698492, ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000303|PubMed:20378371}.; FUNCTION: [Isoform Ets-1 p27]: 作为异构体 c-ETS-1A 的显性负调控因子。 {ECO:0000269|PubMed:19377509}.

组织特异性

Highly expressed within lymphoid cells. Isoforms c-ETS-1A and Ets-1 p27 are both detected in all fetal tissues tested, but vary with tissue type in adult tissues. None is detected in brain or kidney.

亚细胞定位

Nucleus

关键词

3D-structure Acetylation Alternative splicing Cytoplasm DNA-binding Immunity Isopeptide bond Nucleus Phosphoprotein Proteomics identification