前表皮调节素 [裂解为: 表皮调节素 (EPR)]
前表皮调节素 [裂解为: 表皮调节素 (EPR)]
O14944功能描述
EGF受体/EGFR和ERBB4的配体。刺激EGFR和ERBB4酪氨酸磷酸化 (PubMed:9419975)。通过调节血管生成和血管重塑以及刺激细胞增殖，促进炎症、伤口愈合、组织修复和卵母细胞成熟 (PubMed:24631357)。 {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}。
组织特异性
In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
亚细胞定位
[Epiregulin]: Secreted, extracellular space
关键词