EPSTI1 Q96J88

上皮-基质相互作用蛋白1

功能描述

在M1巨噬细胞极化中发挥作用，并且是M1与M2巨噬细胞分化过程中基因表达正确调控所必需的 (By similarity)。可能在巨噬细胞激活后RELA/p65和STAT1的磷酸化及核定位中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q8VDI1}。

组织特异性

Highly expressed in placenta, small intestine, spleen, kidney, thymus, liver, salivary gland and testes. Weakly expressed in breast, skeletal muscle and colon. Highly expressed in breast cancer upon interaction between tumor cells and stromal cells in vitro. Expressed in blood mononuclear cells from patients with systemic lupus erythematosus (SLE).