表皮生长因子受体底物15 (Protein Eps15) (Protein AF-1p)
表皮生长因子受体底物15 (Protein Eps15) (Protein AF-1p)
P42566功能描述
参与细胞生长调节。可能参与有丝分裂信号的调节和细胞增殖的控制。参与配体诱导型受体酪氨酸激酶 (RTK) 类型受体的内化，特别是EGFR。在网格蛋白包被小窝 (CCPs) 的组装中发挥作用。作为高尔基体后运输所需的网格蛋白接头蛋白发挥作用。似乎参与CCPs的成熟，包括内陷或出芽。参与整合素beta-1 (ITGB1) 和转铁蛋白受体 (TFR) 的内吞作用；ITGB1作为DAB2依赖性货物的内化（但TFR不是）似乎需要与DAB2结合。 {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}。
组织特异性
Ubiquitously expressed.
亚细胞定位
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes.
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