EPPIN O95925

Eppin (癌/睾丸抗原71) (CT71) (附睾蛋白酶抑制剂) (蛋白酶抑制剂WAP7) (含Kunitz和WAP结构域的丝氨酸蛋白酶抑制剂样蛋白1) (WAP四硫键核心结构域蛋白7)

功能描述

丝氨酸蛋白酶抑制剂，在雄性生殖和生育能力中发挥重要作用。调节KLK3/PSA（一种丝氨酸蛋白酶）对SEMG1的水解，为射精凝固物中的精子提供抗菌保护，并结合SEMG1从而抑制精子运动。 {ECO:0000269|PubMed:15229136, ECO:0000269|PubMed:17644992}。

组织特异性

In testis, expressed and secreted by Sertoli cells, appearing on the surface of testicular and ejaculate spermatozoa. Expressed in the spermatogonia and the earliest preleptotene spermatocytes. In the epididymis, is expressed and secreted by epithelial cells and covers the surface of epididymal spermatozoa and ciliated epithelial cells (at protein level). Expressed specifically in epididymis and testis. Isoform 2 is expressed only in the epididymis. Weak expression is detected in myoid cells as well as spermatogenic cells.

亚细胞定位

[Isoform 1]: Secreted. Cell surface. Note=Bound to the surface of testicular and on the head and tail of ejaculate spermatozoa.