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ENTPD3 O75355

胞外核苷三磷酸二磷酸水解酶3 (NTPDase 3) (eNTPDase-3) (EC 3.6.1.5) (CD39抗原样3) (胞外ATP二磷酸水解酶3) (胞外ATPDase 3) (胞外ATP酶3) (胞外腺苷三磷酸双磷酸酶3) (HB6)

蛋白质信息 (UniProt)

胞外核苷三磷酸二磷酸水解酶3 (NTPDase 3) (eNTPDase-3) (EC 3.6.1.5) (CD39抗原样3) (胞外ATP二磷酸水解酶3) (胞外ATPDase 3) (胞外ATP酶3) (胞外腺苷三磷酸双磷酸酶3) (HB6)

O75355

功能描述

催化核苷三磷酸 (NTPs) 和核苷二磷酸 (NDPs) 的水解 (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246)。该酶分两步连续去除磷酸基团，通过 NDP 中间体将 NTPs 转化为核苷单磷酸 (NMPs) (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246)。该活性有助于调节细胞外核苷酸水平 (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246)。优先水解 ATP (PubMed:10231536)。不水解 AMP (PubMed:9675246)。 {ECO:0000269|PubMed:10231536, ECO:0000269|PubMed:11300774, ECO:0000269|PubMed:15966724, ECO:0000269|PubMed:9675246}。

组织特异性

Expressed in adult brain, pancreas, spleen and prostate (PubMed:9676430). Moderate or low expression is seen in most tissues (PubMed:9676430). Not expressed in liver and peripheral blood leukocytes (PubMed:9676430).

亚细胞定位

Cell membrane

关键词

Alternative splicing ATP-binding Calcium Cell membrane Disulfide bond Glycoprotein GTP-binding Hydrolase Magnesium Membrane

外部链接

UniProt: O75355
NCBI Gene