胞外核苷三磷酸二磷酸水解酶2 (E-NTPDase 2) (NTPDase 2) (EC 3.6.1.5) (CD39抗原样1) (胞外ATP二磷酸水解酶2) (胞外ATPDase 2) (胞外ATP酶2)
胞外核苷三磷酸二磷酸水解酶2 (E-NTPDase 2) (NTPDase 2) (EC 3.6.1.5) (CD39抗原样1) (胞外ATP二磷酸水解酶2) (胞外ATPDase 2) (胞外ATP酶2)
Q9Y5L3功能描述
催化核苷三磷酸(NTPs)和核苷二磷酸(NDPs)的水解，对三磷酸核苷的偏好性明显高于二磷酸核苷(PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504)。该酶分两步连续去除磷酸基团，通过NDP中间体将NTPs转化为核苷一磷酸(NMPs)(PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504)。该活性有助于调节细胞外核苷酸水平(PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504)。ATP水解的特征是ADP快速积累和AMP形成延迟，反映了有限的ADP水解酶活性(By similarity)。仅微弱水解ADP和UDP，且不水解AMP(PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504)。所有核苷5'-二磷酸的水解速率均低于其相应的三磷酸(By similarity)。 {ECO:0000250|UniProtKB:O35795, ECO:0000269|PubMed:10510450, ECO:0000269|PubMed:12888562, ECO:0000269|PubMed:16101300, ECO:0000269|PubMed:18404504}.; FUNCTION: [Isoform gamma]: 无催化活性。 {ECO:0000269|PubMed:12888562}.; FUNCTION: [Isoform Short]: 无催化活性。 {ECO:0000269|PubMed:12888562}.
组织特异性
Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas (PubMed:9271669). No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes (PubMed:9271669).
亚细胞定位
[Isoform Long]: Cell membrane
关键词