ETS相关转录因子Elf-5 (E74样因子5) (上皮限制性ESE-1相关Ets因子) (上皮特异性Ets转录因子2) (ESE-2)
ETS相关转录因子Elf-5 (E74样因子5) (上皮限制性ESE-1相关Ets因子) (上皮特异性Ets转录因子2) (ESE-2)
Q9UKW6功能描述
转录激活因子，可能在调节角质形成细胞终末分化的后期阶段发挥作用。 {ECO:0000269|PubMed:10506207}.; FUNCTION: Isoform 2 结合含有共有核苷酸核心序列 GGA[AT] 的 DNA 序列。转录激活 SPRR2A 和腮腺特异性 PSP 启动子。 {ECO:0000269|PubMed:10506207}.
组织特异性
Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, kidney and prostate. Weakly expressed in placenta and lung. Isoform 1 and isoform 2 are differentially expressed in different tissues. In the kidney, only isoform 1 was expressed, while prostate expressed both isoforms, with levels of isoform 2 being higher. Expression is up-regulated during keratinocyte differentiation. Several epithelial carcinoma cell lines showed lack of expression.
亚细胞定位
Nucleus
关键词