EP300相互作用分化抑制因子1 (21 kDa pRb相关蛋白) (CREBBP/EP300抑制蛋白1) (E1A样分化抑制因子1) (EID-1)
EP300相互作用分化抑制因子1 (21 kDa pRb相关蛋白) (CREBBP/EP300抑制蛋白1) (E1A样分化抑制因子1) (EID-1)
Q9Y6B2功能描述
与RB1和EP300相互作用，并作为MYOD1反式激活的抑制因子。抑制EP300和CBP组蛋白乙酰转移酶活性。可能参与将细胞周期退出与细胞分化所需基因的转录激活偶联。可能作为NR0B2的候选共抑制因子，可直接连接到转录抑制机制。 {ECO:0000269|PubMed:11073989, ECO:0000269|PubMed:11073990}.
组织特异性
Widely expressed. Most abundantly expressed in heart, skeletal muscle, pancreas, brain and testis. Expressed at much lower levels in placenta and peripheral blood leukocyte. Barely detectable in lung. Also weakly expressed in lung carcinoma A-549 and various leukemia cell lines.
亚细胞定位
Nucleus
关键词