Egl nine 同源蛋白 1 (EC 1.14.11.29) (缺氧诱导因子脯氨酰羟化酶 2) (HIF-PH2) (HIF-脯氨酰羟化酶 2) (HPH-2) (含脯氨酰羟化酶结构域蛋白 2) (PHD2) (SM-20)
Egl nine 同源蛋白 1 (EC 1.14.11.29) (缺氧诱导因子脯氨酰羟化酶 2) (HIF-PH2) (HIF-脯氨酰羟化酶 2) (HPH-2) (含脯氨酰羟化酶结构域蛋白 2) (PHD2) (SM-20)
Q9GZT9功能描述
细胞氧传感器，在常氧条件下催化缺氧诱导因子 (HIF) alpha 蛋白中4-羟脯氨酸的翻译后形成。羟基化 HIF1A 的每个氧依赖降解 (ODD) 结构域（N端，NODD，和C端，CODD）中发现的特定脯氨酸。也羟基化 HIF2A。对 HIF1A 和 HIF1B 的 CODD 位点具有偏好性。羟基化的 HIF 随后通过 von Hippel-Lindau 泛素化复合物被靶向进行蛋白酶体降解。在缺氧条件下，羟基化反应减弱，使 HIF 得以逃避降解，导致其易位至细胞核，与 HIF1B 异二聚化，并增加缺氧诱导基因的表达。EGLN1 是常氧下最重要的同工酶，并通过调节 HIF1 的稳定性，参与各种受缺氧影响的过程，如视网膜和心脏功能中的血管生成。靶蛋白优先通过 LXXLAP 基序被识别。 {ECO:0000269|PubMed:11595184, ECO:0000269|PubMed:12181324, ECO:0000269|PubMed:12351678, ECO:0000269|PubMed:15897452, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:21792862, ECO:0000269|PubMed:25129147}。
组织特异性
According to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to PubMed:12788921; expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle.
亚细胞定位
Cytoplasm
关键词