Ephrin-B1 (EFL-3) (ELK配体) (ELK-L) (EPH相关受体酪氨酸激酶配体2) (LERK-2) [切割为：Ephrin-B1 C端片段 (Ephrin-B1 CTF); Ephrin-B1胞内结构域 (Ephrin-B1 ICD)]
Ephrin-B1 (EFL-3) (ELK配体) (ELK-L) (EPH相关受体酪氨酸激酶配体2) (LERK-2) [切割为：Ephrin-B1 C端片段 (Ephrin-B1 CTF); Ephrin-B1胞内结构域 (Ephrin-B1 ICD)]
P98172功能描述
细胞表面跨膜配体，对应Eph受体，Eph受体是一类受体酪氨酸激酶家族，对于神经元、血管和上皮发育过程中的迁移、排斥和粘附至关重要 (PubMed:7973638, PubMed:8070404)。与位于相邻细胞上的Eph受体结合，导致对邻近细胞的接触依赖性双向信号传导 (PubMed:7973638, PubMed:8070404)。对受体酪氨酸激酶EPHB1/ELK具有高亲和力 (PubMed:7973638, PubMed:8070404)。也能结合EPHB2和EPHB3 (PubMed:8070404)。在体外结合并诱导连合轴突/生长锥塌陷 (By similarity)。可能在限制纵向投射轴突的方向上发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:P52795, ECO:0000269|PubMed:7973638, ECO:0000269|PubMed:8070404}。
组织特异性
Widely expressed (PubMed:7973638, PubMed:8070404). Detected in both neuronal and non-neuronal tissues (PubMed:7973638, PubMed:8070404). Seems to have particularly strong expression in retina, sciatic nerve, heart and spinal cord (PubMed:7973638).
亚细胞定位
Cell membrane
关键词