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EFNA4 P52798

Ephrin-A4 (EPH相关受体酪氨酸激酶配体4) (LERK-4)

蛋白质信息 (UniProt)

Ephrin-A4 (EPH相关受体酪氨酸激酶配体4) (LERK-4)

P52798

功能描述

细胞表面GPI结合型Eph受体配体,Eph受体是一类受体酪氨酸激酶,对于神经元、血管和上皮发育过程中的迁移、排斥和粘附至关重要。无选择性地结合位于相邻细胞上的Eph受体,导致依赖接触的双向信号传导进入邻近细胞。可能在扁桃体中活化的B淋巴细胞与树突状细胞之间的相互作用中发挥作用。

组织特异性

Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines.

亚细胞定位

[Isoform 1]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted

关键词

Alternative splicing Cell membrane Direct protein sequencing Disulfide bond Glycoprotein GPI-anchor Lipoprotein Membrane Proteomics identification Reference proteome