Polycomb蛋白EED (hEED) (胚胎外胚层发育蛋白) (与整合素胞质尾相关联的WD蛋白1) (WAIT-1)
Polycomb蛋白EED (hEED) (胚胎外胚层发育蛋白) (与整合素胞质尾相关联的WD蛋白1) (WAIT-1)
O75530功能描述
Polycomb group (PcG)蛋白。PRC2/EED-EZH2复合物的组分，该复合物甲基化组蛋白H3的'Lys-9'和'Lys-27'，导致受影响靶基因的转录抑制。还能识别'Lys-26'三甲基化的组蛋白H1，其效应是抑制PRC2复合物对核小体组蛋白H3 'Lys-27'的甲基转移酶活性，而H3 'Lys-27'的识别则具有相反的效应，使得这种抑制性标记得以传播。PRC2/EED-EZH2复合物也可能作为DNA甲基转移酶的募集平台，从而连接两个表观遗传抑制系统。被PRC2/EED-EZH2复合物抑制的基因包括HOXC8、HOXA9、MYT1和CDKN2A。 {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:28229514, ECO:0000269|PubMed:9584199}。
组织特异性
Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer.
亚细胞定位
Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
关键词