内皮分化相关因子1 (EDF-1) (多蛋白桥接因子1) (MBF1)
内皮分化相关因子1 (EDF-1) (多蛋白桥接因子1) (MBF1)
O60869功能描述
转录共激活因子，刺激NR5A1及配体依赖的NR1H3/LXRA和PPARG转录活性。增强ATF1、ATF2、CREB1和NR5A1的DNA结合活性。可能通过在细胞质中隔离钙调蛋白来调节一氧化氮合酶活性。可能在内皮细胞分化、激素诱导的心肌细胞肥大和脂质代谢中发挥作用。 {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}.
组织特异性
Expressed in brain, liver, lung, kidney and heart (at protein level). Ubiquitously expressed. More abundant in heart, pancreas, liver, intestine and adipose tissues.
亚细胞定位
Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
关键词