EDEM2 Q9BV94

内质网降解增强α-甘露糖苷酶样蛋白2

功能描述

参与内质网相关降解（ERAD）途径，该途径以N-聚糖依赖性方式靶向错误折叠的糖蛋白进行降解 (PubMed:15537790, PubMed:25092655)。可能通过促进ERAD底物的第一个甘露糖修剪步骤（从Man9GlcNAc2到Man8GlcNAc2）来启动ERAD (PubMed:25092655)。似乎识别并结合靶蛋白中暴露的疏水区域 (By similarity)。 {ECO:0000250|UniProtKB:Q8BJT9, ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:25092655}。

组织特异性

Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.

亚细胞定位

Endoplasmic reticulum lumen