转录因子E2F2 (E2F-2)
转录因子E2F2 (E2F-2)
Q14209功能描述
转录激活因子，通过E2识别位点与DP蛋白协同结合DNA，该位点序列为5'-TTTC[CG]CGC-3'，存在于多个基因的启动子区域，这些基因的产物参与细胞周期调控或DNA复制。DRTF1/E2F复合物在细胞周期从g1期向s期进程的控制中起作用。E2F2以细胞周期依赖性方式特异性结合RB1。
组织特异性
Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
亚细胞定位
Nucleus.
关键词