双特异性丝氨酸/苏氨酸和酪氨酸蛋白激酶 (EC 2.7.12.1) (Dusty蛋白激酶) (Dusty PK) (RIP同源激酶) (受体相互作用丝氨酸/苏氨酸蛋白激酶5) (Sugen激酶496) (SgK496)
双特异性丝氨酸/苏氨酸和酪氨酸蛋白激酶 (EC 2.7.12.1) (Dusty蛋白激酶) (Dusty PK) (RIP同源激酶) (受体相互作用丝氨酸/苏氨酸蛋白激酶5) (Sugen激酶496) (SgK496)
Q6XUX3功能描述
作为成纤维细胞生长因子受体激活下游ERK磷酸化的正调节因子 (PubMed:23862974, PubMed:28157540)。参与caspase依赖性凋亡和caspase非依赖性细胞死亡的调节 (PubMed:15178406)。在皮肤中，它在多种皮肤细胞类型中对抑制UV应激引起的caspase依赖性凋亡起主要作用 (PubMed:28157540)。 {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}。
组织特异性
Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines. Expressed in the skin (PubMed:28157540).
亚细胞定位
Cytoplasm
关键词